Achiasmy Synthesis

Synthesis/review paper on achiasmatic meiosis across the tree of life. Meghann McConnell lead. Combines curated database with phylogenetic context and literature-mined expansion.

Status: active

Current hypothesis:

Achiasmy evolves preferentially in the heterogametic sex as a mechanism to suppress recombination between sex chromosomes; transitions to achiasmy are concentrated in lineages where sex chromosome differentiation is advanced and selection to maintain linkage between sex-determining and sexually antagonistic loci is strongest. The phylogenetic distribution of achiasmy is therefore non-random with respect to sex-determination system and sex chromosome age.

Next action:

Heath to review new figures; Meghann to incorporate HB edits from 14 April

Linked literature

• Long-range linkage maintained male-specific loci on a young Y chromosome prior to recombination shutdown
• Long-read sequencing reveals pre-meiotic gene conversion in sperm
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• Residual double strand break repair during meiosis in budding yeast is promoted by PIF1 , RAD54 and RDH54/TID1
• Altering the dosage of meiotic crossover-associated RING finger proteins affects crossover number and interference in Drosophila
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• Do sex differences in autosomal recombination rates facilitate divergence?
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• The synaptonemal complex: structure, function, and clinical implications†.
• Smek1 ‐Dependent Transcriptional Repression of Usp10 Is Essential for the Progression of Murine Spermatogenesis
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