Achiasmy Synthesis

Synthesis/review paper on achiasmatic meiosis across the tree of life. Meghann McConnell lead. Combines curated database with phylogenetic context and literature-mined expansion.

Status: active

Current hypothesis:

Achiasmy evolves preferentially in the heterogametic sex as a mechanism to suppress recombination between sex chromosomes; transitions to achiasmy are concentrated in lineages where sex chromosome differentiation is advanced and selection to maintain linkage between sex-determining and sexually antagonistic loci is strongest. The phylogenetic distribution of achiasmy is therefore non-random with respect to sex-determination system and sex chromosome age.

Next action:

Heath to review new figures; Meghann to incorporate HB edits from 14 April

Linked literature

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• Reviewer #2 (Public review): ZNHIT1-dependent H2A.Z deposition at meiotic prophase I underlies pachytene gene expression and meiotic progression during male meiosis
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• The synaptonemal complex: structure, function, and clinical implications†.
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